کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2565442 | 1128058 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Antidepressant properties of the 5-HT4 receptor partial agonist, SL65.0155: Behavioral and neurochemical studies in rats
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کلمات کلیدی
TTBSp-CREBTCAHRPFSTi.p.Bcl-25-HTBDNF - BDNF یا فاکتور نورونزایی مشتقشده از مغز forced swim test - آزمون شناور اجباریSDS-PAGE - الکتروفورز ژل پلی آکریل آمیدintraperitoneal - داخل صفاقیTricyclic antidepressant - داروهای ضدافسردگی سه حلقه ایCNS - دستگاه عصبی مرکزیSerotonin - سروتونینcentral nervous system - سیستم عصبی مرکزیbrain derived neurotrophic factor - عامل مغز استخوان مغز استخوان استNeurotrophic factors - عوامل نوروترفیکVascular Endothelial Growth Factor (VEGF) - فاکتور رشد اندوتلیال عروقی (VEGF)Vascular Endothelium Growth Factor - فاکتور رشد اندوتلیوم عروقیB-cell lymphoma-2 - لنفوم سلول B-2Selective serotonin reuptake inhibitor - مهار کننده بازجذب سروتونین انتخابیSSRI - مهارکنندههای بازجذب سروتونینnoradrenaline - نورآدرنالین Horseradish peroxidase - پراکسیداز هوررادیش5-HT4 receptors - گیرنده های 5-HT4
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
This study was undertaken to investigate the potential antidepressant-like properties of SL65.0155, a serotonin 5-HT4 receptor partial agonist, in male rats of the Wistar strain tested in the forced swim test (FST), an experimental model widely used to assess antidepressant-like activity. The expression of hippocampal neurotrophic factors, such as the brain-derived neurotrophic factor (BDNF), the phosphorilated cAMP response element-binding protein (p-CREB), the B cell lymphoma-2 (Bcl-2), the Bax and the vascular endothelium growth factor (VEGF) were also evaluated by Western Blot analysis. Different groups of rats received intraperitoneally (i.p.) injections of SL65.0155 (0.1, 0.5 and 1Â mg/kg), clomipramine (50Â mg/kg), citalopram (15Â mg/kg) or vehicle, respectively, 24, 5 and 1Â h prior to the FST. Compared to the control group, SL65.0155 (0.5 and 1Â mg/kg), clomipramine or citalopram injected animals showed an increased swimming and climbing behavior and reduced immobility time in the FST. Interestingly, this effect was not due to changes in the locomotor activity since all treated groups failed to show any change in motor ability as assessed in the open field test. Western blot analysis of hippocampal homogenates showed an enhancement of p-CREB, BDNF Bcl-2 and VEGF protein levels in SL65.0155 treated groups, but not in citalopram or clomipramine treated groups, used here as positive control. No change was found in Bax expression in any treated group. These findings give further support to the hypothesis that the stimulation of serotonin 5-HT4 receptors may be a therapeutic target for depression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 33, Issue 7, 1 October 2009, Pages 1205-1210
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 33, Issue 7, 1 October 2009, Pages 1205-1210
نویسندگان
Alessandra Tamburella, Vincenzo Micale, Andrea Navarria, Filippo Drago,