کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2565812 | 1128067 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Different sub-anesthetic doses of ketamine increase oxidative stress in the brain of rats
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کلمات کلیدی
CATTBARSNMDAN-methyl-d-aspartateROS - ROSSchizophrenia - اسکیزوفرنی یا شیزوفرنیOxidative stress - تنش اکسیداتیوFree radicals - رادیکال آزادSOD - سدSuperoxide dismutase - سوکسوکس دیسموتازthiobarbituric acid-reactive substances - مواد واکنش پذیر اسید تیوباربیتوریکCatalase - کاتالازKetamine - کتامینReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
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چکیده انگلیسی
Schizophrenia is a complex neuropsychiatric disorder in which symptoms can be classified as either positive, such as delusions and hallucinations, or negative, such as blunted affect and social withdrawal. However, the mechanisms underlying this disease are poorly understood. There is evidence that reactive oxygen species (ROS) play an important role in the pathogenesis of many diseases, particularly those which are neurological and psychiatric in nature. Ketamine has been used to induce a schizophrenia-like condition as an animal model in which to study this condition. In the present study we tested the effects of sub-anesthetic doses of ketamine on various parameters of oxidative stress in the brain of rats. Our results indicate that lipid peroxidation and tissue protein oxidation were affected by varying sub-anesthetic doses of ketamine in multiple cerebral structures. Additionally, the activity of the antioxidant enzymes CAT and SOD was measured and was also found to be altered in most of the structures tested. In conclusion, we observe an increase in oxidative damage marked by an increase in lipid peroxidation, oxidative protein damage and a decrease in enzymatic defenses, in an animal model of schizophrenia. Given that oxidative stress could be related to schizophrenia, these findings may explain, at least in part, the mechanisms underlying in this disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 33, Issue 6, 31 August 2009, Pages 1003-1008
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 33, Issue 6, 31 August 2009, Pages 1003-1008
نویسندگان
Larissa de Oliveira, CecÃlia Marly dos S. Spiazzi, Thaize Bortolin, Leila Canever, Fabricia Petronilho, Franciele Gonçalves Mina, Felipe Dal-Pizzol, João Quevedo, Alexandra I. Zugno,