کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2567126 | 1128313 | 2012 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dexamethasone down-regulates the inflammatory mediators but fails to reduce the tissue injury in the lung of acute pancreatitis rat models
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کلمات کلیدی
rRNANF-κBARDSSTAT-3mRNAMCP-1ICAM-1RT-PCRcDNA - cDNAMPO - DFOROS - ROSpulmonary damage - آسیب ریویcomplementary deoxyribonucleic acid - اسید دز اکسید ریبونوکلئیک مکملribosomal ribonucleic acid - اسید ریبونوکلئیک ریبوزومیanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of variancetumour necrosis factor alpha - تومور نکروز عامل آلفاstandard error of the mean - خطای استاندارد میانگینmessenger ribonucleic acid - رسوب ریبونوکلئیک اسیدAcute respiratory distress syndrome - سندرم دیسترس تنفسی حادcytokine-induced neutrophil chemoattractant - سیتوکین نائوتروفیل شیمیایی کشندهTNF-α - فاکتور نکروز توموری آلفاNuclear factor-kappa B - فاکتور هسته ای-کاپا BSignal transducer and activator of transcription-3 - مبدل سیگنال و فعال کننده رونویسی 3SEM - مدل معادلات ساختاری / میکروسکوپ الکترونی روبشیintercellular adhesion molecule-1 - مولکول چسبندگی بین سلولی -1Adhesion molecules - مولکولهای چسبندگیmyeloperoxidase - میلوپراکسیداز Reverse transcriptase-polymerase chain reaction - واکنش زنجیره ای واکنش زنجیره ای واکنش زنجیره ایmonocyte chemoattractant protein-1 - پروتئین شیمیایی monocyte chemoattractant-1CINC - پنجChemokines - کرموین هاGlucocorticoids - گلوکوکورتیکوئیدهاReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی ریوی و تنفسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Dexamethasone down-regulates the inflammatory mediators but fails to reduce the tissue injury in the lung of acute pancreatitis rat models Dexamethasone down-regulates the inflammatory mediators but fails to reduce the tissue injury in the lung of acute pancreatitis rat models](/preview/png/2567126.png)
چکیده انگلیسی
Pulmonary complications are frequent in the course of acute pancreatitis. We investigate the effects of dexamethasone on lung injury in mild and severe AP. Mild and severe acute pancreatitis was induced in rats by bile-pancreatic duct obstruction and infusion of 3.5% sodium taurocholate into the bile-pancreatic duct, respectively. Dexamethasone (1Â mg/kg) was given by intramuscular injection 1Â h after acute pancreatitis. Plasma amylase activity was measured to evaluate the pancreas damage. Lungs were harvested for analysing mRNA expression of monocyte chemoattractant protein-1 (MCP-1), cytokine-induced neutrophil chemoattractant (CINC), P-selectin and intercellular adhesion molecule-1 (ICAM-1), myeloperoxidase (MPO) activity (as index of neutrophil infiltration) and histological examination. Dexamethasone reduced the hyperamylasemia and hindered the pulmonary upregulation of MCP-1, CINC, P-selectin and ICAM-1, in both mild and severe acute pancreatitis. Despite this, dexamethasone treatment failed to reduce MPO activity and histological alterations developed in lungs during acute pancreatitis, either in bile-pancreatic duct obstruction or sodium taurocholate model. We conclude that pulmonary local factors different from inflammatory mediators contribute to leukocyte recruitment, so that although dexamethasone down-regulated the lung expression of chemokines and adhesion molecules during acute pancreatitis it was not able to prevent leukocyte infiltration, which could be responsible for maintaining the lung injury in either mild or severe acute pancreatitis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pulmonary Pharmacology & Therapeutics - Volume 25, Issue 4, August 2012, Pages 319-324
Journal: Pulmonary Pharmacology & Therapeutics - Volume 25, Issue 4, August 2012, Pages 319-324
نویسندگان
Sara Yubero, Manuel A. Manso, Laura Ramudo, Secundino Vicente, Isabel De Dios,