کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2581686 1130201 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The role of reactive oxygen species and oxidative stress in environmental carcinogenesis and biomarker development
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
The role of reactive oxygen species and oxidative stress in environmental carcinogenesis and biomarker development
چکیده انگلیسی

Although we have greatly benefited from the use of traditional epidemiological approaches in linking environmental exposure to human disease, we are still lacking knowledge in to how such exposure participates in disease development. However, molecular epidemiological studies have provided us with evidence linking oxidative stress with the pathogenesis of human disease and in particular carcinogenesis. To this end, oxidative stress-based biomarkers have proved to be essential in revealing how oxidative stress may be mediating toxicity induced by many known carcinogenic environmental agents. Therefore, throughout this review article, we aim to address the current state of oxidative stress-based biomarker development with major emphasis pertaining to biomarkers of DNA, lipid and protein oxidation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemico-Biological Interactions - Volume 188, Issue 2, 5 November 2010, Pages 334–339
نویسندگان
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