کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2582296 1561656 2006 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antioxidant effect of diphenyl diselenide against sodium nitroprusside (SNP) induced lipid peroxidation in human platelets and erythrocyte membranes: An in vitro evaluation
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Antioxidant effect of diphenyl diselenide against sodium nitroprusside (SNP) induced lipid peroxidation in human platelets and erythrocyte membranes: An in vitro evaluation
چکیده انگلیسی

An in vitro evaluation on the antioxidant effect of diphenyl diselenide (PhSe)2, an organochalcogenide, against sodium nitroprusside (SNP)-induced lipid peroxidation (LPO) was conduced. Human platelets and erythrocyte membranes (ghosts), as well as rat brain homogenates (S1), were pre-incubated with different concentrations of SNP (0–10 μM). All SNP concentrations tested significantly increased LPO in human platelets and S1. Platelets were more sensitive to SNP-induced peroxidative damage when compared to S1. SNP 10 μM decreased glutathione peroxidase (GPx) activity and did not affect glutathione reductase (GR) and catalase (CAT) activities in human platelets. However, ghosts were insensitive to SNP-induced LPO and no changes on GPx, GR and CAT activities were observed. Diphenyl diselenide significantly protected human platelets against SNP-induced LPO and recovered GPx inactivation. This effect was more evident at (PhSe)2 concentrations above 2 μM. The presented results indicate that (PhSe)2 exerts protective effects on SNP-induced oxidative damage in human blood components and in rat brain. These phenomena seem to be related to its thiol peroxidase-like activity and to a possible direct interaction with SNP and derivatives. Based on our results and on literature, diphenyl diselenide can be pointed as a promising antioxidant molecule.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemico-Biological Interactions - Volume 164, Issues 1–2, 1 December 2006, Pages 126–135
نویسندگان
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