کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2582328 1561651 2009 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The human short-chain dehydrogenase/reductase (SDR) superfamily: A bioinformatics summary
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
The human short-chain dehydrogenase/reductase (SDR) superfamily: A bioinformatics summary
چکیده انگلیسی

The short-chain dehydrogenase/reductase (SDR) superfamily represents one of the largest protein superfamilies known to date. Enzymes of this family usually catalyse NAD(P)(H) dependent reactions with a substrate spectrum ranging from polyols, retinoids, steroids and fatty acid derivatives to xenobiotics. We have currently identified 73 SDR superfamily members within the human genome. A status report of the human SDR superfamily is provided in terms of 3D structure determination, co-factor preferences, subcellular localisation and functional annotation. A simple scoring system for measuring structural and functional information (SFS score) has also been introduced to monitor the status of 5 key metrics. Currently there are 17 SDR members with an SFS score of zero indicating that almost a quarter of the human SDR superfamily lacks substantial functional annotation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemico-Biological Interactions - Volume 178, Issues 1–3, 16 March 2009, Pages 99–109
نویسندگان
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