کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2595128 1562187 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Capsaicin prevents ethanol-induced teratogenicity in cultured mouse whole embryos
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Capsaicin prevents ethanol-induced teratogenicity in cultured mouse whole embryos
چکیده انگلیسی

Prenatal exposure to alcohol promotes the level of reactive oxygen species within embryos and results in developmental disorders. In this study, we investigated the effect of capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide), the major pungent ingredient in red peppers, on ethanol-induced teratogenicity in mouse embryos (embryonic days 8.5–10.5). In response to ethanol administration (1.0 μl/ml), developmental parameters such as yolk sac circulation, allantois, heart, hindbrain, midbrain, forebrain, otic and optic systems, branchial bar, olfactory system, forelimb, hindlimb, and somites decreased significantly in comparison with those of control group (p < 0.05). However, the concurrent administration of capsaicin (1 × 10−8 μg/ml or 1 × 10−7 μg/ml) and ethanol significantly ameliorated most of the morphological scores excepting yolk sac circulation and hindlimb scores (p < 0.05). Furthermore, the levels of superoxide dismutase activity and cytoplasmic glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase mRNAs in the ethanol-treated embryos recovered to the levels observed in control embryos by capsaicin co-administration. These results indicate that capsaicin has a protective effect against ethanol-induced teratogenicity via an antioxidative activity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 26, Issues 3–4, November–December 2008, Pages 292–297
نویسندگان
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