کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2600980 | 1133292 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Serum dioxin-like compounds and aromatase (CYP19) expression in endometriotic tissues
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کلمات کلیدی
TEQAHRPCBCyPPCBsGAPDHDENSDLCsPCDDsPCDFsGC-HRMSPCDDPCDFaromatase - آروماتازPeritoneal endometriosis - آندومتریوز پریتوئنEndometriosis - اندومتریوزOvarian endometriosis - اندومتریوز تخمدانDioxin-like compounds - ترکیبات دیوکسین مانندCytochrome P450 - سیتوکروم پی۴۵۰Toxic equivalent - معادل سمیPolychlorobiphenyls - پلی کلروفیل فنیلglyceraldehyde-3-phosphatedehydrogenase - گلیسرالیدید 3-فسفاته هیدروژنازaryl hydrocarbon receptor - گیرنده آرویل هیدروکربنEstrogen receptor - گیرنده استروژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Dioxin-like compounds (DLCs) are suspected etiological factors of endometriosis but their potential mechanisms of action remain elusive. Because endometriosis is an estrogen-dependent disease and since aromatase (CYP19), a key enzyme in estrogen biosynthesis, was recently demonstrated to be expressed in endometriotic lesions, we hypothesized that dioxin-like compounds could modulate local estrogen production through an up-regulation of aromatase. We tested this hypothesis by examining the correlation between serum DLC levels and CYP19 expression in endometriotic tissue obtained from 47 patients with peritoneal, ovarian endometriosis and/or deep endometriotic nodules of the rectovaginal septum. Aromatase expression was assessed by real-time RT-PCR in biopsied endometriotic tissues [peritoneal (n = 19), ovarian (n = 17) endometriosis and deep endometriotic nodules of the recto-vaginal septum (n = 29)]. The relationship between aromatase expression and DLCs was traced by simple regression analysis. DLCs did not appear to be significant determinants of aromatase expression. CYP1A1 expression, measured as a positive control, was found associated with current smoking but not with DLCs. We conclude that DLCs do probably not facilitate the growth of endometriotic lesions by up-regulating the local expression of aromatase.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 167, Issue 3, 15 December 2006, Pages 238-244
Journal: Toxicology Letters - Volume 167, Issue 3, 15 December 2006, Pages 238-244
نویسندگان
Jean-François Heilier, Jacques Donnez, Sylvie Defrere, Valérie Van Kerckhove, Olivier Donnez, Dominique Lison,