کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2788047 1154378 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Small but influential: the role of microRNAs on gene regulatory network and 3′UTR evolution
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Small but influential: the role of microRNAs on gene regulatory network and 3′UTR evolution
چکیده انگلیسی

MicroRNAs (miRNAs) are endogenous ∼22 nucleotide noncoding RNAs that regulate the expression of complementary messenger RNAs (mRNAs). Thousands of miRNA genes have been found in diverse species, and many of them are highly conserved. With the miRNA roles identified in nearly all aspects of biological processes, evidence is mounting that miRNAs could represent a new layer of regulatory network, and their regulatory effect might be much more pervasive than previously suspected. Here we focus on the post-transcriptional level gene regulation of miRNAs in animals and review how the miRNAs act to sustain and shape up the expression profiles of specific cell types; how the miRNAs integrate into the existing gene regulatory networks; and how the miRNAs influence the evolution of 3′UTR of mammalian mRNAs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Genetics and Genomics - Volume 36, Issue 1, January 2009, Pages 1–6
نویسندگان
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