کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3120638 1583293 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Radiotherapy-induced salivary dysfunction: Structural changes, pathogenetic mechanisms and therapies
ترجمه فارسی عنوان
اختلال عملکرد بزاق ناشی از رادیوتراپی: تغییرات ساختاری، مکانیزم های پاتوژنیک و درمان
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
چکیده انگلیسی


• Salivary gland dysfunction is a negative consequence of head and neck radiotherapy.
• Morphologic changes in salivary gland are responsible for glandular dysfunction.
• We address the structural changes in salivary glands caused by radiotherapy.
• Pathogenic mechanisms involved are reviewed.
• Preventive and regenerative therapies for glandular morphology are also reviewed.

PurposeThis review addressed the structural changes observed in salivary glands and pathogenic mechanisms resulting from oxidative stress caused by radiotherapy. The preventive and regenerative therapies for altered acinar morphology and glandular function were also reviewed. Among acute and late microscopic alterations in glandular tissue, there are particularly changes indicative of cell death, hypovascularization, formation of fibrous tissue and edema. A critical role was identified for the Akt–MDM2–p53 pathway in the suppression of DNA damage-induced apoptosis in acinar cells. Prophylactic treatment with pilocarpine, cevilemine, bethanechol and isoproterenol has shown a positive effect on salivary flow, but lasting results have not been observed. Growth factors, histamine and lidocaine, have also demonstrated radioprotective effects on the salivary glands. Stem cell preservation and transplantation may be an alternative to maintain tissue homeostasis and thus allow glandular regeneration.ConclusionKnowledge of the structural changes observed in the salivary glands contributes to proving the short- and long-term efficacy of the therapies investigated. It is important to know the mechanisms involved in radiation-induced damage, since the control of the pathogenic mechanisms can inhibit the initial process of tissue degeneration. The challenge for investigators is to protect normal cells selectively, without promoting tumor growth.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Oral Biology - Volume 60, Issue 12, December 2015, Pages 1802–1810
نویسندگان
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