Leukotrienes deficiency

There are many diseases connected with deficiency of leukotrienes, but all people suffering from this are also exposed to infection. This is a result of low amounts of cysLTs and LTB4, which are potent inflammatory mediators, resulting in the host defenses of people with decreased levels of leukotrienes being impaired. Bacteria exploit this condition and many patients with conditions such as HIV or diabetes mellitus die due to complications. It is important for doctors to know in which cases they should monitor such other parameters as lung functions.