Affinity of IgE and IgG against cross-reactive carbohydrate determinants on plant and insect glycoproteins

Low binding affinity of anti-CCD IgE cannot be the reason for the observed clinical insignificance of IgE against plant/insect glycan epitopes. Notably, the affinity of IgG to CCDs is higher than that to protein allergens, and it may therefore function as blocking antibody.