کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3202035 1201965 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Staphylococcus aureus sensitization and allergic disease in early childhood: Population-based birth cohort study
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Staphylococcus aureus sensitization and allergic disease in early childhood: Population-based birth cohort study
چکیده انگلیسی

BackgroundStaphylococcus aureus–secreted enterotoxins (SEs) may be involved in the pathophysiology of atopic diseases.ObjectiveWe investigated the role of SEs in allergic diseases during early childhood (using the mixture of SE-specific IgEs [SE-mix] as a marker).MethodsChildren (N = 510) were followed from birth to age 5 years (repeated questionnaires, IgE to inhalant and food allergens, lung function [spirometry, plethysmography], airway reactivity [dry air challenge]). We measured SE-mix specific IgE (SE-A, SE-C, toxic shock syndrome toxin 1) by using fluorescence immunoassay.ResultsWe found no association between rhinitis and SE-mix sensitization. Children with eczema were more frequently SE-mix–sensitized than children without (17.4% vs 8.3%; P = .02). SE-mix sensitization rate increased significantly with increasing eczema severity (no eczema, mild, moderate/severe: 8.3%, 14.8%, 42.9%; P = .003) and remained independently associated with eczema in a multivariate model adjusting for total IgE (adjusted odds ratio, 2.19; 95% CI, 1.05-4.56; P = .04). SE-mix sensitization was associated with current wheeze in the univariate but not the multivariate model. Among wheeze phenotypes, persistent wheezers were most commonly sensitized to SE-mix (never, transient, late-onset, persistent: 8.5%, 3.8%, 7.7%, 17.6%; P = .05). Among wheezers, those SE-mix–sensitized had significantly higher airway reactivity compared with those nonsensitized (mean FEV1 change, mL [95% CI]: −59 [−121, 3] vs 19 [−10.2, 48.9]; P = .04), with little difference after adjusting for atopy.ConclusionWe found differences in SE-mix IgE antibodies between healthy 5-year-old children and children with eczema and wheeze. The proportion of patients sensitized to SE-mix increases with increasing disease severity.Clinical implicationsStaphylococcal enterotoxins are potential modifiers of childhood wheeze and eczema.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Allergy and Clinical Immunology - Volume 119, Issue 4, April 2007, Pages 930–936
نویسندگان
, , , , , , , ,