کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3202035 | 1201965 | 2007 | 7 صفحه PDF | دانلود رایگان |
BackgroundStaphylococcus aureus–secreted enterotoxins (SEs) may be involved in the pathophysiology of atopic diseases.ObjectiveWe investigated the role of SEs in allergic diseases during early childhood (using the mixture of SE-specific IgEs [SE-mix] as a marker).MethodsChildren (N = 510) were followed from birth to age 5 years (repeated questionnaires, IgE to inhalant and food allergens, lung function [spirometry, plethysmography], airway reactivity [dry air challenge]). We measured SE-mix specific IgE (SE-A, SE-C, toxic shock syndrome toxin 1) by using fluorescence immunoassay.ResultsWe found no association between rhinitis and SE-mix sensitization. Children with eczema were more frequently SE-mix–sensitized than children without (17.4% vs 8.3%; P = .02). SE-mix sensitization rate increased significantly with increasing eczema severity (no eczema, mild, moderate/severe: 8.3%, 14.8%, 42.9%; P = .003) and remained independently associated with eczema in a multivariate model adjusting for total IgE (adjusted odds ratio, 2.19; 95% CI, 1.05-4.56; P = .04). SE-mix sensitization was associated with current wheeze in the univariate but not the multivariate model. Among wheeze phenotypes, persistent wheezers were most commonly sensitized to SE-mix (never, transient, late-onset, persistent: 8.5%, 3.8%, 7.7%, 17.6%; P = .05). Among wheezers, those SE-mix–sensitized had significantly higher airway reactivity compared with those nonsensitized (mean FEV1 change, mL [95% CI]: −59 [−121, 3] vs 19 [−10.2, 48.9]; P = .04), with little difference after adjusting for atopy.ConclusionWe found differences in SE-mix IgE antibodies between healthy 5-year-old children and children with eczema and wheeze. The proportion of patients sensitized to SE-mix increases with increasing disease severity.Clinical implicationsStaphylococcal enterotoxins are potential modifiers of childhood wheeze and eczema.
Journal: Journal of Allergy and Clinical Immunology - Volume 119, Issue 4, April 2007, Pages 930–936