کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3202562 1201974 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Efficacy and safety of ciclesonide nasal spray for the treatment of seasonal allergic rhinitis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Efficacy and safety of ciclesonide nasal spray for the treatment of seasonal allergic rhinitis
چکیده انگلیسی

BackgroundAllergic rhinitis (AR), an inflammatory disease of the nasal mucosa, affects approximately 25% of adults and 40% of children in the United States. Ciclesonide nasal spray is a corticosteroid being developed as a hypotonic formulation for AR.ObjectiveWe sought to evaluate the efficacy, safety, and tolerability of ciclesonide nasal spray in adult and adolescent patients with seasonal AR (SAR).MethodsIn this double-blind study patients (age, ≥12 years) were randomized to receive 200 μg of intranasal ciclesonide (n = 164) or placebo (n = 163) once daily for 28 days. The primary measure was morning and evening patient-assessed reflective total nasal symptom score (TNSS). Additionally, instantaneous TNSSs, physician-assessed overall nasal signs and symptoms severity, and the results of the Rhinoconjunctivitis Quality of Life Questionnaire were evaluated. Adverse events were monitored throughout the study.ResultsCiclesonide significantly improved average morning and evening reflective and instantaneous TNSSs compared with placebo over days 1 to 14 (P < .001). Improvements were also noted over days 1 to 28 (P < .001) and over days 15 to 28 (P = .011). Ciclesonide was well tolerated.ConclusionIntranasal ciclesonide was superior to placebo in relieving nasal symptoms in adult and adolescent patients with SAR. These results confirm the dose range–finding study in patients with SAR and support the efficacy of ciclesonide in AR.Clinical implicationsIn a clinical setting ciclesonide was shown to be safe and effective in the treatment of SAR in adolescent and adult patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Allergy and Clinical Immunology - Volume 118, Issue 5, November 2006, Pages 1142–1148
نویسندگان
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