کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3203209 1201991 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Protective effect of Schistosoma mansoni infection on allergic airway inflammation depends on the intensity and chronicity of infection
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Protective effect of Schistosoma mansoni infection on allergic airway inflammation depends on the intensity and chronicity of infection
چکیده انگلیسی

BackgroundPopulation studies have suggested that chronic and intense helminth infections, in contrast to acute and mild helminth infections, might suppress allergic airway inflammation.ObjectiveWe sought to address the question of how the chronicity and intensity of helminth infections affect allergic airway inflammation in a well-defined experimental model.MethodsC57/Bl6 mice were infected with Schistosoma mansoni, followed by sensitization and challenge with ovalbumin (OVA), and different stages and intensities of infection were studied. To this end, mice were analyzed at 8, 12, or 16 weeks, representing the acute, intermediate, or chronic phases of infection, respectively.ResultsLung lavage eosinophilia, peribronchial inflammation, and OVA-induced airway hyperresponsiveness were increased during acute infection but significantly decreased when infection progressed into chronicity. Decreases in lung lavage eosinophilia were parasite density–dependent. Similar levels of OVA-specific IgE were found during all phases of infection, whereas both OVA-specific and parasite-specific TH2 cytokine levels were significantly reduced during chronic infection. Inhibition of airway inflammation could be transferred to OVA-sensitized recipient mice by B cells and CD4+ T cells from spleens of chronically, but not acutely, infected mice. This suppression was IL-10–dependent.ConclusionDuring chronic, but not acute, helminth infections, suppressive mechanisms are induced that regulate immune reactions to inhaled allergens. These data confirm human epidemiologic observations in a well-controlled animal model.Clinical implicationsCharacterization of chronic helminth infection–induced regulatory mechanisms will help in the development of future therapeutics to treat or prevent allergic disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Allergy and Clinical Immunology - Volume 120, Issue 4, October 2007, Pages 932–940
نویسندگان
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