کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3203328 | 1201995 | 2007 | 5 صفحه PDF | دانلود رایگان |
In some patients, asthma control is improved by combining inhaled corticosteroids with long-acting β2-agonists. However, fluctuating asthma control and exacerbations can still occur. The STAY study evaluated whether, in patients with moderate to severe asthma, replacing a short-acting β2-agonist reliever with the combination of budesonide/formoterol as reliever would both provide rapid symptom relief and reduce asthma exacerbations. The study evaluated 2760 patients with asthma (4-80 years) randomized to budesonide 400 μg twice daily (bid) and terbutaline as reliever, budesonide/formoterol 100/6 μg bid and terbutaline as reliever, or budesonide/formoterol 100/6 μg bid both as maintenance and reliever. Children (age 4-11 years) used a once-daily maintenance dose. Budesonide/formoterol as maintenance and reliever significantly reduced severe exacerbation risk by 45% to 47% compared with the other 2 treatments and improved symptoms, awakenings, and lung function. The benefit was seen in patients of all ages. Subsequent studies have revealed that this beneficial effect of budesonide/formoterol as maintenance and reliever requires both components of the combination.
Journal: Journal of Allergy and Clinical Immunology - Volume 119, Issue 6, June 2007, Pages 1332–1336