کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3204191 | 1587141 | 2014 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Severe Asthma in Children
ترجمه فارسی عنوان
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کلمات کلیدی
FeNOGERDERSACTPEFFVCNAEPPEGDATSACQICSN/A - N / ALong-acting β-agonist - آگونیست β-طولانی مدتEuropean Respiratory Society - انجمن تنفسی اروپاAmerican Thoracic Society - انجمن قلب آمریکاesophagogastroduodenoscopy - اوسوفاژوگاسترودوداندوسکوپی، اندوسکوپی دستگاه گوارش فوقانیexhaled nitric oxide - اکسید نیتریک اکسید شدهNational Asthma Education and Prevention Program - برنامه آگاهی ملی و پیشگیری از آسمgastroesophageal reflux disease - بیماری ریفلاکس معده به مریAsthma control test - تست کنترل آسمcomputed tomography - توموگرافی کامپیوتری یا سی تی اسکن یا مقطعنگاری رایانهایPeak expiratory flow - جریان انقباض قلهNot available - در دسترس نیستLABA - سودbody mass index - شاخص توده بدنBMI - شاخص توده بدنیforced vital capacity - ظرفیت حیاتی اجباریReview - مرورAsthma Control Questionnaire - پرسشنامه کنترل آسمInhaled corticosteroid - کورتیکواستروئیدهای استنشاقیGINA - گینا
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
چکیده انگلیسی
Severe asthma in children is characterized by sustained symptoms despite treatment with high doses of inhaled corticosteroids or oral corticosteroids. Children with severe asthma may fall into 2 categories, difficult-to-treat asthma or severe therapy-resistant asthma. Difficult-to-treat asthma is defined as poor control due to an incorrect diagnosis or comorbidities, or poor adherence due to adverse psychological or environmental factors. In contrast, treatment resistant is defined as difficult asthma despite management of these factors. It is increasingly recognized that severe asthma is a highly heterogeneous disorder associated with a number of clinical and inflammatory phenotypes that have been described in children with severe asthma. Guideline-based drug therapy of severe childhood asthma is based primarily on extrapolated data from adult studies. The recommendation is that children with severe asthma be treated with higher-dose inhaled or oral corticosteroids combined with long-acting β-agonists and other add-on therapies, such as antileukotrienes and methylxanthines. It is important to identify and address the influences that make asthma difficult to control, including reviewing the diagnosis and removing causal or aggravating factors. Better definition of the phenotypes and better targeting of therapy based upon individual patient phenotypes is likely to improve asthma treatment in the future.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Allergy and Clinical Immunology: In Practice - Volume 2, Issue 5, SeptemberâOctober 2014, Pages 489-500
Journal: The Journal of Allergy and Clinical Immunology: In Practice - Volume 2, Issue 5, SeptemberâOctober 2014, Pages 489-500
نویسندگان
Theresa W. MD, MS, Leonard B. MD, Anne M. CPNP, PhD,