Palmoplantar pustules and osteoarticular pain in a 42-year-old woman

Key teaching points
• Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome is characterized by distinctive osteoarticular manifestations and a spectrum of neutrophilic dermatoses.
• The most common dermatologic manifestations include palmoplantar pustulosis, acne conglobata, and acne fulminans.
• SAPHO syndrome should be considered in patients presenting osteoarticular pain, particularly involving the anterior chest wall and/or spine, and neutrophilic skin lesions.