کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3205939 1587559 2012 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Germline melanoma susceptibility and prognostic genes: A review of the literature
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی امراض پوستی
پیش نمایش صفحه اول مقاله
Germline melanoma susceptibility and prognostic genes: A review of the literature
چکیده انگلیسی

In recent years, there have been increasing efforts to identify germline genetic variants that may alter melanoma susceptibility and prognosis. The findings of these studies have indicated the presence of rare, high-penetrance alleles with large effects, such as CDKN2A and CDK4, more common, moderately penetrant genes like MC1R, and very common, low-penetrance polymorphisms with small effects that are related to pigmentation, nevus count, immune responses, DNA repair, metabolism, and the vitamin D receptor. The study of these low-penetrance single nucleotide polymorphisms is relatively new; thus many of them are termed ‘candidate melanoma susceptibility or prognostic genes.’ This review summarizes the research on germline polymorphisms that have been implicated in melanoma susceptibility and prognosis in order to provide a framework for additional studies to meet the ultimate goal of predicting a patient's risk of, and prognosis in, cutaneous malignant melanoma.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American Academy of Dermatology - Volume 67, Issue 5, November 2012, Pages 1055–1067
نویسندگان
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