کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3206444 1587576 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Adverse effects of propranolol when used in the treatment of hemangiomas: A case series of 28 infants
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی امراض پوستی
پیش نمایش صفحه اول مقاله
Adverse effects of propranolol when used in the treatment of hemangiomas: A case series of 28 infants
چکیده انگلیسی

BackgroundInfantile hemangioma (IH) is a frequently encountered tumor with a potentially complicated course. Recently, propranolol was discovered to be an effective treatment option.ObjectiveTo describe the effects and side effects of propranolol treatment in 28 children with (complicated) IH.MethodsA protocol for treatment of IH with propranolol was designed and implemented. Propranolol was administered to 28 children (21 girls and 7 boys, mean age at onset of treatment: 8.8 months).ResultsAll 28 patients had a good response. In two patients, systemic corticosteroid therapy was tapered successfully after propranolol was initiated. Propranolol was also an effective treatment for hemangiomas in 4 patients older than 1 year of age. Side effects that needed intervention and/or close monitoring were not dose dependent and included symptomatic hypoglycemia (n = 2; 1 patient also taking prednisone), hypotension (n = 16, of which 1 is symptomatic), and bronchial hyperreactivity (n = 3). Restless sleep (n = 8), constipation (n = 3) and cold extremities (n = 3) were observed.LimitationsClinical studies are necessary to evaluate the incidence of side effects of propranolol treatment of IH.ConclusionsPropranolol appears to be an effective treatment option for IH even in the nonproliferative phase and after the first year of life. Potentially harmful adverse effects include hypoglycemia, bronchospasm, and hypotension.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American Academy of Dermatology - Volume 65, Issue 2, August 2011, Pages 320–327
نویسندگان
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