کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3208939 1587627 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Oral curcumin in the treatment of moderate to severe psoriasis vulgaris: A prospective clinical trial
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی امراض پوستی
پیش نمایش صفحه اول مقاله
Oral curcumin in the treatment of moderate to severe psoriasis vulgaris: A prospective clinical trial
چکیده انگلیسی

BackgroundThere is a need for safe, inexpensive, and effective psoriasis therapies. Many anecdotal accounts of patients' successful treatment with the alternative medicine curcumin exist.ObjectiveWe sought to determine the safety and efficacy of oral curcumin in patients with psoriasis.MethodsWe conducted a phase II, open-label, Simon's two-stage trial of 4.5 g/d of oral curcuminoid C3 complex in patients with plaque psoriasis. End points included improvement in Physicians Global Assessment score, Psoriasis Area and Severity Index score, and safety end points throughout the study.ResultsThe intention-to-treat analysis response rate was 16.7% (95% confidence interval: 2%, 48%) and both responders achieved a Psoriasis Area and Severity Index 75 score. There were no study-related adverse events that necessitated participant withdrawal.LimitationsSmall sample size and lack of placebo group are limitations.ConclusionThe response rate was low and possibly caused by a placebo effect or the natural history of psoriasis. Large placebo-controlled studies are necessary before recommending oral curcumin as a psoriasis treatment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American Academy of Dermatology - Volume 58, Issue 4, April 2008, Pages 625–631
نویسندگان
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