کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3209528 | 1587645 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Methotrexate-associated lymphoproliferative disorder in a patient with rheumatoid arthritis presenting in the skin
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
امراض پوستی
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![عکس صفحه اول مقاله: Methotrexate-associated lymphoproliferative disorder in a patient with rheumatoid arthritis presenting in the skin Methotrexate-associated lymphoproliferative disorder in a patient with rheumatoid arthritis presenting in the skin](/preview/png/3209528.png)
چکیده انگلیسی
A 91-year-old woman who had been taking methotrexate for approximately 5 years for rheumatoid arthritis developed papules and nodules on her face that enlarged during 6 months. A series of biopsy specimens demonstrated a lymphoplasmacytic infiltrate with increasingly atypical histopathologic features that resembled diffuse large B-cell lymphoma. Epstein-Barr virus was not identified. Withdrawal of methotrexate resulted in complete resolution of all lesions within 8 weeks. This case illustrates the rare occurrence of methotrexate-associated lymphoproliferative disorder with primary presentation in the skin and documents clinical and histopathologic progression from early changes to fully developed lesions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American Academy of Dermatology - Volume 56, Issue 4, April 2007, Pages 686–690
Journal: Journal of the American Academy of Dermatology - Volume 56, Issue 4, April 2007, Pages 686–690
نویسندگان
Loren E. Clarke, Jacqueline Junkins-Hopkins, John T. Seykora, Donald J. Adler, Rosalie Elenitsas,