کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3356055 | 1591581 | 2008 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
hsBAFF enhances activity of NK cells by regulation of CD4+ T lymphocyte function
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کلمات کلیدی
TALL-1Helper T lymphocytesNCSB cell activating factor belonging to the TNF familyIFN-γRIACD4+ T lymphocyteIL-2BLySBCMATACIB cell maturation antigen - آنتی ژن بالغ بر سلول Benzyme linked immunosorbent assay - آنزیم تست ایمونوسیورسانس مرتبط استinterferon-gamma - اینترفرون گاماInterleukin-2 - اینترلوکین-۲BAFF - بافELISA - تست الیزاradioimmunoassay - رادیوایمونواسیNK cell - سلول NKNatural killer cell - سلول قاتل طبیعیCytotoxic T lymphocytes - لنفوسیت های T سیتوتوکسیکB lymphocyte stimulator - محرک لنفوسیت B
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
B cell activating factor belonging to the TNF family (BAFF, also called BLyS, TALL-1, THANK, or zTNF4) is an important survival factor for B cells, and is able to regulate T cell activation. Recently, we have demonstrated that human soluble BAFF (hsBAFF) potently elevates NK cell activity of murine splenic cells in vivo. In this study, we further show that hsBAFF markedly enhanced NK cell activity of in vitro mouse splenic cells. Purified NK cell activities treated with hsBAFF in the presence of IL-2 or IFN-γ, but not with hsBAFF alone were obviously elevated. hsBAFF strongly increased the activity of NK cells co-incubated with mixed T and B lymphocytes or T lymphocytes alone, but not with B lymphocytes alone. We also found that culture supernatants, from mixed T and B lymphocytes or T lymphocytes alone, but not from B lymphocytes alone post-hsBAFF treatment, effectively increased NK cell activity, and noticed that IL-2 and IFN-γ levels significantly increased in the culture supernatants of hsBAFF-treated T lymphocytes. Of importance, we pinpointed that hsBAFF elicited robust population of CD4+ T lymphocytes in vitro, and further demonstrated that hsBAFF induced significantly high IL-2 and IFN-γ secretion of CD4+ T lymphocytes. These findings indicate that hsBAFF results in the elevation of NK cell activity by regulation of CD4+ T lymphocytes contributing to IL-2 and IFN-γ generation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunology Letters - Volume 120, Issues 1â2, 30 September 2008, Pages 96-102
Journal: Immunology Letters - Volume 120, Issues 1â2, 30 September 2008, Pages 96-102
نویسندگان
Wei Zhang, Ling Wen, Xinhua Huang, Junqing Liang, Wei Gao, Shuangquan Zhang, Long Chen,