کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3391520 1221055 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Augmentation of antibody responses by retinoic acid and costimulatory molecules
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Augmentation of antibody responses by retinoic acid and costimulatory molecules
چکیده انگلیسی
Antibody production is crucial for a successful vaccine response. Beyond the ability of vitamin A (VA) and its active metabolite, all-trans-retinoic acid (RA) to restore growth in VA-deficient animals, supplementation with VA and/or treatment with RA can augment antibody responses in both VA-deficient and VA-adequate animals. RA alone, and in combination with stimuli that are ligands for the Toll-like receptor family, can augment the adaptive immune response leading to a heightened primary antibody response, and a stronger recall response upon restimulation. Mechanisms may include regulation of cell populations, type 1/type 2 cytokines, and B cell-related transcription factors, leading to accelerated B cell maturation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Immunology - Volume 21, Issue 1, February 2009, Pages 42-50
نویسندگان
, , ,