کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4177482 1276424 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antibodies to the N-Methyl-D-Aspartate Receptor and Other Synaptic Proteins in Psychosis
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Antibodies to the N-Methyl-D-Aspartate Receptor and Other Synaptic Proteins in Psychosis
چکیده انگلیسی

This review concentrates on the evidence for autoantibodies to cell surface synaptic proteins in psychosis and schizophrenia. We and others have recently found antibodies to the N-methyl-D-aspartate receptor in first-episode psychosis. We describe the evidence for pathogenicity and disease-relevance of these antibodies, which builds on the novel field in neuroimmunology of cell surface antibody–associated central nervous system disorders. Relevant autoantibodies in psychosis and schizophrenia are likely to be those directed to cell surface proteins, in which the likelihood of pathogenicity is greater. We discuss the evidence for this from the field of paraneoplastic neurologic syndromes and the discovery of novel cell surface antigen central nervous system autoimmune syndromes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biological Psychiatry - Volume 75, Issue 4, 15 February 2014, Pages 284–291
نویسندگان
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