کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4178700 1276509 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Endogenous Opioid Release in the Human Brain Reward System Induced by Acute Amphetamine Administration
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Endogenous Opioid Release in the Human Brain Reward System Induced by Acute Amphetamine Administration
چکیده انگلیسی

BackgroundWe aimed to demonstrate a pharmacologically stimulated endogenous opioid release in the living human brain by evaluating the effects of amphetamine administration on [11C]carfentanil binding with positron emission tomography (PET).MethodsTwelve healthy male volunteers underwent [11C]carfentanil PET before and 3 hours after a single oral dose of d-amphetamine (either a “high” dose, .5 mg/kg, or a sub-pharmacological “ultra-low” dose, 1.25 mg total dose or approximately .017 mg/kg). Reductions in [11C]carfentanil binding from baseline to post-amphetamine scans (ΔBPND) after the “high” and “ultra-low” amphetamine doses were assessed in 10 regions of interest.Results[11C]carfentanil binding was reduced after the “high” but not the “ultra-low” amphetamine dose in the frontal cortex, putamen, caudate, thalamus, anterior cingulate, and insula.ConclusionsOur findings indicate that oral amphetamine administration induces endogenous opioid release in different areas of human brain, including basal ganglia, frontal cortex areas, and thalamus. The combination of an amphetamine challenge and [11C]carfentanil PET is a practical and robust method to probe the opioid system in the living human brain.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biological Psychiatry - Volume 72, Issue 5, 1 September 2012, Pages 371–377
نویسندگان
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