کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4180291 1276597 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The Effects of Prolonged Stress and APOE Genotype on Memory and Cortisol in Older Adults
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
The Effects of Prolonged Stress and APOE Genotype on Memory and Cortisol in Older Adults
چکیده انگلیسی

BackgroundChronic elevations in cortisol associated with prolonged stress have been associated with memory loss, as has the apolipoprotein E gene (APOE-ε4) genotype. Combined effects of stress and APOE status on memory and cortisol in humans have not been studied.MethodsA semistructured interview with standardized scoring was used to measure stress level and univariate analysis of variance to assess effects of stress and APOE-ε4 status on memory and salivary cortisol in 91 nondemented subjects (mean age 78.8 years).ResultsLow-stress subjects performed better than high-stress subjects on delayed recall of stories (p = .04), word lists (p = .02), and visual designs (p = .04). APOE-ε4-negative subjects obtained better scores than ε4-positive subjects on immediate (p = < .01) and delayed (p < .01) recall of visual designs. Significant stress by APOE-ε4 interaction effects on memory (p = .03) and cortisol (p < .01) resulted from consistently worse memory and higher cortisol concentrations in the high stress, ε4-positive group.ConclusionsThese findings are consistent with a model in which prolonged exposure of older, nondemented individuals to stress in the presence of an ε4 allele leads to memory decline. Further studies will assess whether stress and APOE-ε4 interact to increase the risk of developing Alzheimer’s disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biological Psychiatry - Volume 62, Issue 5, 1 September 2007, Pages 472–478
نویسندگان
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