Chronic Carbamazepine Administration Reduces N-Methyl-D-Aspartate Receptor-Initiated Signaling via Arachidonic Acid in Rat Brain

Chronic CBZ administration to rats blocks increments in the AA signal k*, and in PGE2 and TXB2 concentrations that are produced by NMDA in vehicle-treated rats. The clinical action of antimanic drugs might involve inhibition of brain NMDAR-mediated signaling involving AA and its metabolites.