کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4180751 1276618 2007 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Using the Autism Diagnostic Interview—Revised to Increase Phenotypic Homogeneity in Genetic Studies of Autism
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Using the Autism Diagnostic Interview—Revised to Increase Phenotypic Homogeneity in Genetic Studies of Autism
چکیده انگلیسی

BackgroundMany chromosomal regions for susceptibility to autism spectrum disorders (ASDs) have been identified, but few have reached genomewide significance. In response, researchers have attempted to increase the power of their analyses by stratifying samples to increase phenotypic homogeneity. Although homogeneity has typically been defined by a single variable, resultant groups often differ in other dimensions that may be directly pertinent. Group differences in age, gender, IQ, and measures of autism severity are examined as related to Autism Diagnostic Interview—Revised (ADI-R) domains previously used for subsetting or Quantitative Trait Analysis (QTL).MethodsParticipants were research participants and clinic referrals for assessment of possible autism. Assessments included the ADI-R, Autism Diagnostic Observation Schedule, Vineland Adaptive Behavior Scales, and a developmental or cognitive test. Data were collected for 983 individuals, ages 4 to 52 years, with diagnoses of autism and ASDs.ResultsFindings suggest that, of several potential grouping variables, only restricted and repetitive behaviors associated with Insistence on Sameness were independent of age, IQ, and autism severity.ConclusionsResults emphasize the potential unintended effects of stratification and the importance of understanding such interrelationships between phenotypic characteristics when defining subgroups or performing QTL.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biological Psychiatry - Volume 61, Issue 4, 15 February 2007, Pages 438–448
نویسندگان
, , , , ,