کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4359946 1301126 2013 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Protein interaction networks in innate immunity
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Protein interaction networks in innate immunity
چکیده انگلیسی


• Individual proteomic technologies are sensitive and can be used synergistically.
• Assembly of cellular protein complexes results from many regulatory decisions.
• Interaction proteomics is useful for mapping both single protein complexes and entire pathways.
• Large-scale analyses of host–pathogen interaction have elucidated fundamental principles.

The immune response to pathogens is controlled by complex and tightly regulated molecular networks. Recent technological advances have empowered approaches to investigate innate immune signaling and monitor host–pathogen interactions at a systems level. Protein complexes are key players in pathogen recognition and integrate much of the host molecular responses that occur at the transcriptional and translational level. The ability to monitor protein complex abundance, dynamics, and composition is therefore important to understand the ability of cells to mount the appropriate immune response. Here, we focus on current proteomics technologies applied to identify the protein complexes involved, and highlight recent studies illustrating the power of these approaches to unravel how the dedicated molecular machinery is integrated with other cellular processes to safeguard homeostasis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 34, Issue 12, December 2013, Pages 610–619
نویسندگان
, , ,