کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4411939 | 1307615 | 2010 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of human pharmaceutical Carbamazepine on the quality parameters and oxidative stress in common carp (Cyprinus carpio L.) spermatozoa
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کلمات کلیدی
Fish spermatozoaTBARSLPOGPXNADPHCbzDMSO - DMSOROS - ROSAntioxidant - آنتی اکسیدانPolyunsaturated fatty acids - اسید چرب اشباع نشدهPUFA - اسید چرب چند غیراشباعMotility - تحرکDimethyl sulfoxide - دیمتیل سولفواکسیدViability - زنده ماندنSOD - سدSuperoxide dismutase - سوکسوکس دیسموتازthiobarbituric acid-reactive substances - مواد واکنش پذیر اسید تیوباربیتوریکnicotinamide adenine dinucleotide phosphate - نیکوتین آمید adenine dinucleotide phosphateLipid peroxidation - پراکسیداسیون لیپیدCarbonyl protein - پروتئین کربونیلcarbamazepine - کاربامازپینglutathione reductase - گلوتاتیون ردوکتازglutathione peroxidase - گلوتاتیون پراکسیدازReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
شیمی زیست محیطی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effect of human pharmaceutical Carbamazepine on the quality parameters and oxidative stress in common carp (Cyprinus carpio L.) spermatozoa Effect of human pharmaceutical Carbamazepine on the quality parameters and oxidative stress in common carp (Cyprinus carpio L.) spermatozoa](/preview/png/4411939.png)
چکیده انگلیسی
The effects of CBZ (a human pharmaceutical commonly present in aquatic environment) on the quality parameters and oxidative stress of common carp spermatozoa were investigated in vitro. Fish spermatozoa were incubated with different concentration of CBZ (0.2, 2.0 and 20 mg Lâ1) for 2 h. Results revealed that the percentage of spermatozoa motile and velocity were decreased significantly at higher concentration of CBZ (2.0 and 20 mg Lâ1) and a dose-dependent reduction was observed. But the viability of fish spermatozoa was not affected significantly in all CBZ treatment groups. After 2 h exposure of CBZ at higher test concentration (2.0 or 20 mg Lâ1), oxidative stress was apparent as reflected by the significant higher LPO and CP levels in fish spermatozoa, as well as the significant inhibition of antioxidant enzymes activities including SOD, GR and GPx. In short, CBZ can induce ROS stress in fish spermatozoa, which could impair the sperm quality and antioxidant defense system. Our results suggested that the use of fish spermatozoa in vitro assays may provide a novel and efficiently means for monitoring residual pharmaceutical in aquatic environment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemosphere - Volume 80, Issue 5, July 2010, Pages 530-534
Journal: Chemosphere - Volume 80, Issue 5, July 2010, Pages 530-534
نویسندگان
Zhi-Hua Li, Ping Li, Marek Rodina, Tomas Randak,