کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5142597 | 1496269 | 2017 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Propagation rate constants for the peroxidation of sterols on the biosynthetic pathway to cholesterol
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کلمات کلیدی
7-DehydrocholesterolDHCR7SLOS2,2′-azobis(4-methoxy-2,4-dimethylvaleronitrile)MeOAMVN7-DHC - 7 DHCSterols - استرول هاOxysterols - اکسستیرولFree radicals - رادیکال آزادRadical clock - ساعت رادیکالSmith-Lemli-Opitz Syndrome - سمیت اسمیت-لملی-اپیتسMass spectrometry - طیف سنجی جرمیRate constants - نرخ ثابتPeroxidation - پراکسیداسیونHPLC - کروماتوگرافی مایعی کاراhigh-performance liquid chromatography - کروماتوگرافی مایعی کارا
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The free radical chain autoxidation of cholesterol and the oxidation products formed, i.e. oxysterols, have been the focus of intensive study for decades. The peroxidation of sterol precursors to cholesterol such as 7-dehydrocholesterol (7-DHC) and desmosterol as well as their oxysterols has received less attention. The peroxidation of these sterol precursors can become important under circumstances in which genetic conditions or exposures to small molecules leads to an increase of these biosynthetic intermediates in tissues and fluids. 7-DHC, for example, has a propagation rate constant for peroxidation some 200 times that of cholesterol and this sterol is found at elevated levels in a devastating human genetic condition, Smith-Lemli-Opitz syndrome (SLOS). The propagation rate constants for peroxidation of sterol intermediates on the biosynthetic pathway to cholesterol were determined by a competition kinetic method, i.e. a peroxyl radical clock. In this work, propagation rate constants for lathosterol, zymostenol, desmosterol, 7-dehydrodesmosterol and other sterols in the Bloch and Kandutsch-Russell pathways are assigned and these rate constants are related to sterol structural features. Furthermore, potential oxysterols products are proposed for sterols whose oxysterol products have not been determined.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemistry and Physics of Lipids - Volume 207, Part B, October 2017, Pages 51-58
Journal: Chemistry and Physics of Lipids - Volume 207, Part B, October 2017, Pages 51-58
نویسندگان
Connor R. Lamberson, Hubert Muchalski, Kari B. McDuffee, Keri A. Tallman, Libin Xu, Ned A. Porter,