کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5209009 1503019 2007 18 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthetic polypeptides for biomedical applications
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthetic polypeptides for biomedical applications
چکیده انگلیسی
This article summarizes recent developments in the synthesis of copolypeptides from polymerization of α-amino acid-N-carboxyanhydrides (NCAs), focusing on their development for potential use in biomedical applications. Block and random copolypeptides of controlled dimensions (including: molecular weight, sequence, composition, and molecular weight distribution) can now be prepared. This review summarizes recent efforts to develop polypeptide hydrogels for tissue engineering applications, polypeptide membranes for therapeutic delivery, polypeptide adhesives for use as surgical sealants, antimicrobial polypeptides for treatment against infectious diseases, and immunomodulating polypeptides for treatment of autoimmune disorders. While these materials show great potential, much development is still required before they will be useful in some of these applications. However, the ability to prepare polypeptides with predictable structure and function puts these applications within reach.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Polymer Science - Volume 32, Issues 8–9, August–September 2007, Pages 858-875
نویسندگان
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