Triglyceride increase in the core of high-density lipoproteins augments apolipoprotein dissociation from the surface: Potential implications for treatment of apolipoprotein deposition diseases

Increasing triglyceride content in the core of an HDL particle augments apolipoprotein release from the HDL surface. This released protein can bind to other HDL, get degraded or get misfolded in amyloid.301