کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5501956 | 1534939 | 2017 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A chronic increase of corticosterone age-dependently reduces systemic DNA damage from oxidation in rats
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کلمات کلیدی
Fecal corticosterone metabolites8-oxo-7,8-dihydro-2-deoxyguanosineFCM8-oxoGuoCA3CA18-oxodGGluR8-oxo-7,8-dihydroguanosine - 8-اکسو-7،8-دی هیدروگنوزینDNA - DNA یا اسید دزوکسی ریبونوکلئیکROS - ROSUPLC-MS/MS - UPLC-MS / MSStress - استرس یا فشار روانیdeoxyribonucleic acid - اسید deoxyribonucleicRNA - اسید ریبونوکلئیکribonucleic acid - اسید ریبونوکلئیکDepression - افسردگیanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceELISA - تست الیزاCNS - دستگاه عصبی مرکزیAging - سالخوردگیcentral nervous system - سیستم عصبی مرکزیCSF - مایع مغزی نخاعیCerebrospinal fluid - مایع مغزی نخاعیHPA-axis - محور HPAHypothalamic-pituitary-adrenal axis - محور هیپوتالاموس-هیپوفیز-آدرنالCORT - کورتCorticosterone - کورتیکوسترونGlucocorticoids - گلوکوکورتیکوئیدهاReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Stress and depression are associated with an acceleration of brain and bodily aging; effects which have been attributed to chronic elevations of glucocorticoids. We tested the hypothesis that a three week administration of stress-associated levels of corticosterone (CORT, the principal rodent glucocorticoid) would increase systemic and CNS DNA and RNA damage from oxidation; a phenomenon known to be centrally involved in the aging process. We also hypothesized that older individuals would be more sensitive to this effect and that the chronic CORT administration would exacerbate age-related memory decline. Young and old male Sprague-Dawley rats were non-invasively administered CORT by voluntary ingestion of nut paste containing either CORT (25Â mg/kg) or vehicle for a total of 22 days. CORT increased the 24Â h urinary excretion of the hormone to the levels previously observed after experimental psychological stress and caused a downregulation of the glucocorticoid receptor in the CA1 area of the hippocampus. Contrary to our hypothesis, 24Â h excretion of 8-oxodG/8-oxoGuo (markers of DNA/RNA damage from oxidation) was reduced in CORT-treated young animals, whereas old animals showed no significant differences. In old animals, CORT caused a borderline significant reduction of RNA oxidation in CNS, which was paralleled by a normalization of performance in an object location memory test. To our knowledge, this is the first demonstration that chronic stress-associated levels of CORT can reduce nucleic acid damage from oxidation. These findings contradict the notion of elevated CORT as a mediator of the accelerated aging observed in stress and depression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 104, March 2017, Pages 64-74
Journal: Free Radical Biology and Medicine - Volume 104, March 2017, Pages 64-74
نویسندگان
Anders Jorgensen, Otto Kalliokoski, Kristin Forsberg, Katrine Breitenstein, Allan Weimann, Trine Henriksen, Jann Hau, Gitta Wörtwein, Henrik Enghusen Poulsen, Martin Balslev Jorgensen,