کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5510315 | 1538983 | 2017 | 35 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Molecular details on gilthead sea bream (Sparus aurata) sensitivity to low water temperatures from 1H NMR metabolomics
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کلمات کلیدی
hepato-somatic indexEPAATP/ADPAMPFDRTMAOSFAMUFAFSIRASHSInuclear magnetic resonance - رزونانس مغناطیسی هستهایAquaculture - آبزی پروریp-value - ارزش pThermal stress - استرس حرارتیArachidonic acid - اسید آراشیدونیکFatty acid - اسید چربPolyunsaturated fatty acids - اسید چرب اشباع نشدهPUFA - اسید چرب چند غیراشباعsaturated fatty acids - اسیدهای چرب اشباع شدهmonounsaturated fatty acids - اسیدهای چرب غیر اشباعTrimethylamine N-oxide - تریمتییلامین N-اکسیدNMR - تشدید مغناطیسی هستهای fold change - تغییر در برابرARA - در حال حاضرDHA - دوکوساهگزائنوئیک اسیدSignificance level - سطح اهمیتRecirculating aquaculture system - سیستم آبزی پروری در حال تکرار استphosphatidylcholine - فسفاتیدیل کولینphosphatidylethanolamine - فسفاتیدیلتانولامینGilthead sea bream - ماهی قزل آلا سرخ شدهMetabolomics - متابولومیک
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Molecular details on gilthead sea bream (Sparus aurata) sensitivity to low water temperatures from 1H NMR metabolomics Molecular details on gilthead sea bream (Sparus aurata) sensitivity to low water temperatures from 1H NMR metabolomics](/preview/png/5510315.png)
چکیده انگلیسی
Biometric and metabolic responses of gilthead sea bream to cold challenge are described following a growth trial divided into three water temperature steps, namely cooling, cold maintenance and recovery. Experimental data provide a useful description of fish response to thermal stress at both zootechnical and molecular level. Although no mortality has been observed, Nuclear Magnetic Resonance-based metabolomics confirms the marked sensitivity of this fish species to low water temperature, and explains some key molecular events associated to fish response to cold. Increase in hepatosomatic index is associated to liver fat accumulation, as a consequence of lipid mobilization from muscle and other extrahepatic tissues, and metabolic rearrangements linked to homeoviscous adaptation of cellular membranes are observed. Following primary responses to descending temperature from 18 °C to 11 °C, the energetic metabolism (insulin signaling, glycolysis) is first clearly affected; then, at constant low water temperature (11 °C), the most perturbed metabolic pathways are related to methionine cycle in liver, while osmoregulatory function is exerted by TMAO in muscle. Water temperature recovery from 11 °C to 18 °C stimulates gluconeogenesis and glycogen synthesis activities at hepatic level, although the rate of a thermo-compensatory response seems to be slower than that of the cooling phase. The obtained results are intended to guide novel high-performance feed formulations for gilthead sea bream reared during winter.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology - Volume 204, February 2017, Pages 129-136
Journal: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology - Volume 204, February 2017, Pages 129-136
نویسندگان
Riccardo Melis, Roberta Sanna, Angela Braca, Elia Bonaglini, Roberto Cappuccinelli, Hanno Slawski, Tonina Roggio, Sergio Uzzau, Roberto Anedda,