کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5511410 | 1539859 | 2017 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Bis(monoacylglycero)phosphate inhibits TLR4-dependent RANTES production in macrophages
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
ABCTLR4MbCDIRF3oxLDLMYD88IL-6LPSTRIF - Trif بهlysobisphosphatidic acid - اسید لیسوبیسفسفیدیدPolyunsaturated fatty acids - اسید چرب اشباع نشدهPUFA - اسید چرب چند غیراشباعmyeloid differentiation primary response 88 - اولین پاسخ تفکیک پذیری مایولا 88interleukin 6 - اینترلوکین 6tumor necrosis factor α - تومور نکروز عامل αATP-binding cassette transporter - حمل کننده کاسه اتصال ATPMembrane order - سفارش غشاءInterferon regulatory factor 3 - عامل تنظیمی اینترفرون 3TNF-α - فاکتور نکروز توموری آلفاOxidized low-density lipoprotein - لیپوپروتئین با چگالی کم اکسید شدهlipopolysaccharide - لیپوپلی ساکاریدmethyl-β-cyclodextrin - متیل-β-سیکلوکودکسترینBMP - مدیریت فرایند کسب و کارRANTES - مطالبcholesterol - کلسترولToll-like receptor 4 - گیرنده تله مانند 4Toll-like receptors - گیرنده های پولی مانند
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Bis(monoacylglycero)phosphate inhibits TLR4-dependent RANTES production in macrophages Bis(monoacylglycero)phosphate inhibits TLR4-dependent RANTES production in macrophages](/preview/png/5511410.png)
چکیده انگلیسی
Toll-like receptor 4 (TLR4) is the receptor for bacterial lipopolysaccharide (LPS) triggering production of pro-inflammatory cytokines which help eradicate the bacteria but could also be harmful when overproduced. The signaling activity of TLR4 is modulated by cholesterol level in cellular membranes, which in turn is affected by bis(monoacylglycero)phosphate (BMP), a phospholipid enriched in late endosomes. We found that exogenously added BMP isomers become incorporated into the plasma membrane and intracellular vesicles of macrophages and strongly reduced LPS-stimulated production of a chemokine RANTES, which was correlated with inhibition of interferon regulatory factor 3 (IRF3) controlling Rantes expression. To investigate the mechanism underlying the influence of BMP on TLR4 signaling we applied Laurdan and studied the impact of BMP incorporation on lipid packing, a measure for membrane order. Enrichment of model and cellular membranes with BMP significantly reduced their order and the reduction was maintained during stimulation of cells with LPS. This effect of BMP was abolished by enrichment of macrophages with cholesterol. In parallel, the inhibitory effect of BMP exerted on the TLR4-dependent phosphorylation of IRF3 was also reversed. Taken together our results indicate that BMP reduces the order of macrophage membranes which contributes to the inhibition of TLR4-dependent RANTES production.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The International Journal of Biochemistry & Cell Biology - Volume 83, February 2017, Pages 15-26
Journal: The International Journal of Biochemistry & Cell Biology - Volume 83, February 2017, Pages 15-26
نویسندگان
Anna Ciesielska, Hanna Sas-Nowosielska, Katarzyna Kwiatkowska,