کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5536526 | 1402293 | 2017 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dengue vaccine safety signal: Immune enhancement, waning immunity, or chance occurrence?
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کلمات کلیدی
VCDADEAntibody dependent enhancement - افزایش وابستگی آنتی بادیImmunization - ایمن سازیSafety - ایمنیDengue - دنگAdverse Events Following Immunization - رویدادهای ناخوشایند بعد از ایمن سازیconfidence interval - فاصله اطمینانVaccine - واکسنClinical trial - کارآزمایی بالینیVaccine efficacy - کارآیی واکسن
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A new dengue vaccine was associated with increased risk of hospitalized virologically-confirmed disease during year 3 of follow-up among children age 2-5Â years. Among hypotheses to explain this finding, we could not distinguish definitively between antibody dependent enhancement, waning immunity, or chance occurrence. However, any theory must account for the following: (a) the signal occurred mainly because of decreased dengue among controls rather than increased dengue among vaccinees; (b) among 48 data points, a statistically significant increase in hospitalization among vaccinated children occurred for only one age group, during one year, and in one region; (c) cumulative risk was similar for vaccinated vs. control children age 2-5Â years at the end of year 5 and lower for vaccinated vs. control children among older age groups; (d) the protective effect of vaccine against hospitalization decreased from years 1-2 to years 3-5 of follow-up for all age groups and regions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 35, Issue 27, 14 June 2017, Pages 3452-3456
Journal: Vaccine - Volume 35, Issue 27, 14 June 2017, Pages 3452-3456
نویسندگان
Bradford D. Gessner, Neal Halsey,