کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5557001 1560558 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ontogeny, aging, and gender-related changes in hepatic multidrug resistant protein genes in rats
ترجمه فارسی عنوان
تغییرات آنتوگنین، پیری و جنسیت در ژنهای پروتئینی مقاوم به چندین دارو در موش صحرایی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

Multidrug resistance proteins (Mrps) are efflux transporters playing important roles in endogenous substances and xenobiotics transport out of the liver. Children, elderly, gender and physio-pathological conditions could influence their expression and result in changes in drug disposition.AimThis study was aimed to examine the development-, aging-, and sex-dependent changes in Mrp1-4 and ATP-binding cassette sub-family G member 2 (Abcg2) gene expressions in livers of rats.Main methodsThe livers from male and female SD rats at development (− 2, 1,7,14,21,28,35, and 60 d) and aging (28, 60, 180 and 540 d) were collected and total RNA was isolated, purified and subjected to real-time RT-PCR analysis.Key findingsResults showed that expression of Mrp1 was low, while Abcg2 and Mrp2 were the high in the liver. Mrp1 expression decreased with maturity but remained constant to 540 d, while Mrp3 and 4 increased with liver development, reached the peak with maturity at 35-60 days of age, and slightly reduced with aging. Mrp2 and Abcg2 were high at 7 days of age and maintained at relative high levels till maturity, while Abcg2 was reduced during aging. Females had higher Mrp3 and Abcg2 mRNA expression than male rats, while male rats had higher Mrp2 and Mrp4 mRNA expression.SignificanceThe expression of hepatic Mrp1-4 and Abcg2 mRNA during development, aging in male and female rats was characterized, which could be fundamental to our understanding of age- and sex-associated variations in drug disposition in children, elderly, and women.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 170, 1 February 2017, Pages 108-114
نویسندگان
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