کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5557743 | 1560931 | 2017 | 51 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Interleukin 32, inflammation and cancer
ترجمه فارسی عنوان
اینترلوکین 32، التهاب و سرطان
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کلمات کلیدی
IL-33HUVECFLSCMLBLPAICDTLRHMGB1GM-CSFLCCNODphorbol 12-myristate 13-acetateTNBSPR3CTCLULBP2IL-32MOG35–55PLAAphospholipase A2-activating proteinPBMCCRSSCCConcanavalin ADSSLPSIBDPMA - LDC هاAdenocarcinomas - آدنوکارسینوماRheumatoid arthritis - آرتریتروماتوئیدEST - استOsteoarthritis - استئوآرتریت(آرتروز)Trinitrobenzene sulfonic acid - اسید سولفونیک TrinitrobenzeneInterleukin-32 - اینترلوکین 32Interleukin-33 - اینترلوکین 33Con A - با AInflammatory disease - بیماری التهابیChronic obstructive pulmonary disease - بیماری مزمن انسدادی ریهCOPD - بیماری مزمن انسدادی ریهInflammatory bowel disease - بیماریهای التهابی رودهrapid amplification of cDNA ends - تقویت سریع cDNA به پایان می رسدExpressed Sequence Tag - تکرار اظهار نظرToll-like receptor - تیالآرNon-obese diabetic - دیابتی غیر چاقیTherapeutic approaches - رویکردهای درمانیChronic rhinosinusitis - رینویوزیت مزمنCancer - سرطانHuman umbilical vein endothelial cell - سلول اندوتلیالی ورید ناقل انسانیperipheral blood mononuclear cells - سلول های تک هسته ای خون محیطیSézary syndrome - سندرم سزاریdextran sodium sulfate - سولفات سدیم سدیمCytokine - سیتوکینendoplasmic reticulum - شبکه آندوپلاسمی granulocyte-macrophage colony-stimulating factor - عامل گرانولوسیت-ماکروفاژ colony-stimulating factorMycosis fungoides - قارچ MycosisCutaneous T-cell lymphoma - لنفوم پوستی TChronic myeloid leukemia - لوسمی میلوئید مزمنbacterial lipoprotein - لیپوپروتئین باکتریاییlipopolysaccharide - لیپوپلی ساکاریدfibroblast-like synoviocytes - مانند سینوویوسیت های فیبروبلاستactivation-induced cell death - مرگ سلولی ناشی از فعال شدنRace - مسابقهHIV - ویروس نقص ایمنی انسانی human immunodeficiency virus - ویروس نقص ایمنی انسانیHuman papilloma virus - ویروس پاپیلومای انسانیHPV - ویروس پایپلوم انسانیHigh-mobility group box 1 protein - پروتئین جعبه 1 پروتئین گروه تحریر بالاproteinase 3 - پروتئیناز 3
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
چکیده انگلیسی
Interleukin-32 (IL-32) is a novel cytokine involved in inflammation and cancer development. IL-32 gene consists of eight small exons, and IL-32 mRNA has nine alternative spliced isoforms, and was thought to be secreted because it contains an internal signal sequence and lacks a transmembrane region. IL-32 is initially expressed selectively in activated T cells by mitogen and activated NK cells and their expression is strongly augmented by microbes, mitogens, and other cytokines. The IL-32 is induced mainly by pathogens and pro-inflammatory cytokines, but IL-32 is more prominent in immune cells than in non-immune tissues. The IL-32 transcript is expressed in various human tissues and organs such as the spleen, thymus, leukocyte, lung, small intestine, colon, prostate, heart, placenta, liver, muscle, kidney, pancreas, and brain. Cytokines are critical components of cell signaling pathways that are involved in the regulation of cell growth, metabolism, hormone signaling, immune regulation and a variety of other physiological functions. Earlier studies have demonstrated that IL-32 regulates cell growth, metabolism and immune regulation and is therefore involved in the pathologic regulator or protectant of inflammatory diseases. Previous studies defined that IL-32 is upregulated in the patients with several inflammatory diseases, and is induced by inflammatory responses. However, several reports suggested that IL-32 is downregulated in several inflammatory diseases including asthma, HIV infection disease, neuronal diseases, metabolic disorders, experimental colitis and metabolic disorders. IL-32 is also involved in various cancer malignancies including renal cancer, esophageal cancer and hepatocellular carcinoma, lung cancer, gastric cancer, breast cancer, pancreatic cancer, lymphoma, osteosarcoma, breast cancer, colon cancer and thyroid carcinoma. Other studies suggested that IL-32 decreases tumor development including cervical cancer, colon cancer and prostate cancer, melanoma, pancreatic cancer, liver cancer and chronic myeloid leukemia. Nevertheless, review articles that discuss the roles and its mechanism of IL-32 isoforms focusing on the therapeutic approaches have not yet been reported. In this review article, we will discuss recent findings regarding IL-32 in the development of diseases and further discuss therapeutic approaches targeting IL-32. Moreover, we will suggest that IL-32 could be the target of several diseases and the therapeutic agents for targeting IL-32 may have potential beneficial effects for the treatment of inflammatory diseases and cancers. Future research should open new avenues for the design of novel therapeutic approaches targeting IL-32.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology & Therapeutics - Volume 174, June 2017, Pages 127-137
Journal: Pharmacology & Therapeutics - Volume 174, June 2017, Pages 127-137
نویسندگان
Jin Tae Hong, Dong Ju Son, Chong Kil Lee, Do-Young Yoon, Dong Hun Lee, Mi Hee Park,