کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5559469 | 1561580 | 2017 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evaluation of antioxidant activity of phenolic fractions from the leaves and petals of dandelion in human plasma treated with H2O2 and H2O2/Fe
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کلمات کلیدی
GRASMDATBARSTBAABTSDPPHDMSO - DMSOHydrogen peroxide - آب اکسیژنهThiobarbituric acid - اسید تیوباربیتوریکgenerally recognized as safe - به طور کلی به عنوان امن شناخته شده استOxidative stress - تنش اکسیداتیوDimethylsulfoxide - دیمتیل سولفواکسیدAntioxidant activity - فعالیت آنتیاکسیدانیDandelion - قاصدکmalonyldialdehyde - مالونی دی آلدئیدthiobarbituric acid reactive substances - مواد واکنش پذیر اسید تیوباربیتوریکH2O2 - هیدروژن پراکسیدLipid peroxidation - پراکسیداسیون لیپید
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Evaluation of antioxidant activity of phenolic fractions from the leaves and petals of dandelion in human plasma treated with H2O2 and H2O2/Fe Evaluation of antioxidant activity of phenolic fractions from the leaves and petals of dandelion in human plasma treated with H2O2 and H2O2/Fe](/preview/png/5559469.png)
چکیده انگلیسی
Taraxacum officinale (dandelion) is a widespread perennial of the Asteraceae family. Dandelion is a rich source of different bioactive compounds, including phenolic compounds, terpenes, carbohydrates, proteins, fatty acids, vitamin and minerals. However, the content of phenolics in tested extracts by various authors was not always well described. Dandelion is also a commonly available food with a long history of human use and as such poses little risk of harm. In this study, we focused on four different phenolic fractions from leaves and petals of dandelion, which might be of great interest. The objective was to investigate the antioxidant properties of the phenolic fractions from dandelion leaves and petals in vitro. Effects of four different phenolic fractions from dandelion leaves and petals on the production of thiobarbituric acid reactive substances (TBARS, a marker of lipid peroxidation) in human plasma were studied in vitro. Their antioxidant properties against human plasma protein carbonylation and oxidation of protein thiols induced by a strong biological oxidant - hydrogen peroxide (H2O2) or H2O2/Fe (a donor of hydroxyl radicals) were also examined. The tested fractions of dandelion (0.5-50 μg/mL; the incubation time - 30 min) inhibited plasma lipid peroxidation induced by H2O2 or H2O2/Fe. However, their antioxidant properties were not concentration-dependent. All tested samples also inhibited plasma protein carbonylation and oxidation of thiol groups in plasma proteins stimulated by oxidants (H2O2 and OHâ). The obtained results suggest that four tested dandelion fractions, especially phenolic fractions from petals which are recognized as better than leaves source of flavonoids, may be a new and promising source of natural compounds with antioxidant activity beneficial for diseases-associated with oxidative stress, and with changes of hemostasis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemico-Biological Interactions - Volume 262, 25 January 2017, Pages 29-37
Journal: Chemico-Biological Interactions - Volume 262, 25 January 2017, Pages 29-37
نویسندگان
Dariusz JÄdrejek, Bogdan Kontek, Bernadetta Lis, Anna Stochmal, Beata Olas,