Dedicator of cytokinesis 8-deficient CD4+ TÂ cells are biased to a TH2 effector fate at the expense of TH1 and TH17Â cells

Investigations into the DOCK8-deficient CD4+ T cells provided an explanation for some of the clinical features of this disorder: the TH2 bias is likely to contribute to atopic disease, whereas defects in TH1 and TH17 cells compromise antiviral and antifungal immunity, respectively, explaining the infectious susceptibility of DOCK8-deficient patients.