|کد مقاله||کد نشریه||سال انتشار||مقاله انگلیسی||ترجمه فارسی||نسخه تمام متن|
|5648456||1587499||2017||7 صفحه PDF||سفارش دهید||دانلود رایگان|
BackgroundAntibiotic therapy is commonly used to treat hidradenitis suppurativa (HS). Although concern for antibiotic resistance exists, data examining the association between antibiotics and antimicrobial resistance in HS lesions are limited.ObjectiveWe sought to determine the frequency of antimicrobial resistance in HS lesions from patients on antibiotic therapy.MethodologyA cross-sectional analysis was conducted on 239 patients with HS seen at the Johns Hopkins Medical Institutions from 2010 through 2015.ResultsPatients using topical clindamycin were more likely to grow clindamycin-resistant Staphylococcus aureus compared with patients using no antibiotics (63% vs 17%; PÂ =Â .03). Patients taking ciprofloxacin were more likely to grow ciprofloxacin-resistant methicillin-resistant S aureus compared with patients using no antibiotics (100% vs 10%; PÂ =Â .045). Patients taking trimethoprim/sulfamethoxazole were more likely to grow trimethoprim/sulfamethoxazole-resistant Proteus species compared with patients using no antibiotics (88% vs 0%; PÂ <Â .001). No significant antimicrobial resistance was observed with tetracyclines or oral clindamycin.LimitationsData on disease characteristics and antimicrobial susceptibilities for certain bacteria were limited.ConclusionsAntibiotic therapy for HS treatment may be inducing antibiotic resistance. These findings highlight the importance of stewardship in antibiotic therapy for HS and raise questions regarding the balance of antibiotic use versus potential harms associated with antibiotic resistance.
Journal: Journal of the American Academy of Dermatology - Volume 76, Issue 2, February 2017, Pages 309-313.e2