کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5649191 | 1407120 | 2017 | 30 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Critical Role for Skin-Derived Migratory DCs and Langerhans Cells in TFH and GC Responses after Intradermal Immunization
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کلمات کلیدی
PBSPLAintradermalTFHDLNddC - DDCdiphtheria toxin - توکسین دیفتریDendritic cell - سلول دندریتیکDermal dendritic cell - سلول دندریتیک پوستLangerhans cell - سلول لانگرهانسPhosphate buffered saline - فسفات بافر شورGerminal center - مرکز ژرمینالpoly(d,l-lactic acid) - پلی (d، l-لاکتیک اسید)T follicular helper - کمکی به فولیکول TDraining lymph node - گره لنفاوی تخلیهLymph node - گره های لنفاوی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
امراض پوستی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Critical Role for Skin-Derived Migratory DCs and Langerhans Cells in TFH and GC Responses after Intradermal Immunization Critical Role for Skin-Derived Migratory DCs and Langerhans Cells in TFH and GC Responses after Intradermal Immunization](/preview/png/5649191.png)
چکیده انگلیسی
Intradermal delivery of antigen represents a potent route of immunization that involves multiple blood- and skin-derived dendritic cell subpopulations endowed with specialized functions and dynamics in their ability to prime naïve CD4+ T cells in the draining lymph nodes. However, their individual contributions to the generation of CD4+ T follicular helper (TFH) cells and germinal centers (GCs) remain to be understood. We found that intradermal immunization of mice with a particle-based vaccine induced robust TFH and germinal center B-cell responses in skin draining lymph nodes, which were completely abrogated when skin cell emigration was prevented. However, in this later condition, both lymph node-resident and blood-derived inflammatory cells access the antigen in the draining lymph nodes but are not able to induce TFH cell differentiation. Rather, only skin-derived dendritic cells up-regulated key genes related to TFH cell development in the draining lymph nodes. Depletion of Langerhans cells partially abrogated TFH and germinal center B-cell responses. Thus, after intradermal immunization, only skin-derived migratory dendritic cells, including Langerhans cells, permit the generation of TFH cells and germinal centers. Identifying the relative contributions of tissue and lymphoid organ dendritic cell subsets in generating humoral immune responses is of great importance for the development of tailored vaccines.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Investigative Dermatology - Volume 137, Issue 9, September 2017, Pages 1905-1913
Journal: Journal of Investigative Dermatology - Volume 137, Issue 9, September 2017, Pages 1905-1913
نویسندگان
Clément Levin, Olivia Bonduelle, Charles Nuttens, Charlotte Primard, Bernard Verrier, Alexandre Boissonnas, Béhazine Combadière,