کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5649333 | 1407122 | 2017 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Requirement of Zinc Transporter SLC39A7/ZIP7 for Dermal Development to Fine-Tune Endoplasmic Reticulum Function by Regulating Protein Disulfide Isomerase
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کلمات کلیدی
PDIMSCUPRZIPSmall interfering RNA - RNA تداخل کوچکsiRNA - siRNAMesenchymal stem cell - سلول های بنیادی مزانشیمیendoplasmic reticulum - شبکه آندوپلاسمی DEG - شماKnockdown - نابودیknockout - ناکاوتUnfolded protein response - پاسخ پروتئین آشکارprotein disulfide isomerase - پروتئین دیسولفید ایزومرازDifferentially expressed gene - ژن بیان شده متفاوت است
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
امراض پوستی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Skin is the first area that manifests zinc deficiency. However, the molecular mechanisms by which zinc homeostasis affects skin development remain largely unknown. Here, we show that zinc-regulation transporter-/iron-regulation transporter-like protein 7 (ZIP7) localized to the endoplasmic reticulum plays critical roles in connective tissue development. Mice lacking the Slc39a7/Zip7 gene in collagen 1-expressing tissue exhibited dermal dysplasia. Ablation of ZIP7 in mesenchymal stem cells inhibited cell proliferation thereby preventing proper dermis formation, indicating that ZIP7 is required for dermal development. We also found that mesenchymal stem cells lacking ZIP7 accumulated zinc in the endoplasmic reticulum, which triggered zinc-dependent aggregation and inhibition of protein disulfide isomerase, leading to endoplasmic reticulum dysfunction. These results suggest that ZIP7 is necessary for endoplasmic reticulum function in mesenchymal stem cells and, as such, is essential for dermal development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Investigative Dermatology - Volume 137, Issue 8, August 2017, Pages 1682-1691
Journal: Journal of Investigative Dermatology - Volume 137, Issue 8, August 2017, Pages 1682-1691
نویسندگان
Bum-Ho Bin, Jinhyuk Bhin, Juyeon Seo, Se-Young Kim, Eunyoung Lee, Kyuhee Park, Dong-Hwa Choi, Teruhisa Takagishi, Takafumi Hara, Daehee Hwang, Haruhiko Koseki, Yoshinobu Asada, Shinji Shimoda, Kenji Mishima, Toshiyuki Fukada,