کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5649779 | 1407131 | 2017 | 35 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Infections in Moderate to Severe Psoriasis Patients Treated with Biological Drugs Compared to Classic Systemic Drugs: Findings from the BIOBADADERM Registry
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
امراض پوستی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Information regarding the safety of biological drugs prescribed to psoriasis patients on daily and long-term bases is insufficient. We used data from the BIOBADADERM registry (Spanish Registry of Adverse Events for Biological Therapy in Dermatological Diseases) to generate crude rates of infection during therapy with systemic drugs, including biological drugs (infliximab, etanercept, adalimumab, and ustekinumab) and nonbiological drugs (acitretin, cyclosporine, and methotrexate). We also calculated unadjusted and adjusted risk ratios (RRs) (with propensity score adjustment) of infection, serious infections, and recurrent infections of systemic therapies compared with methotrexate, using Poisson regression. Our study included records of 2,153 patients (7,867.5 person-years). The adjusted RR of overall infection was significantly increased in the groups treated with adalimumab with methotrexate (adjusted RRÂ = 2.13, 95% confidence interval [CI]Â = 1.2-3.7), infliximab (adjusted RRÂ =Â 1.71, 95% CIÂ =Â 1.1-2.65), cyclosporine (adjusted RRÂ = 1.58, 95% CIÂ = 1.17-2.15), ustekinumab with methotrexate (adjusted RRÂ =Â 1.56, 95% CIÂ = 1.08-2.25), and etanercept (adjusted RRÂ = 1.34, 95% CI: 1.02-1.76) compared with methotrexate alone. Cyclosporine had a significant risk of serious infection (adjusted RRÂ = 3.12, 95% CIÂ =Â 1.1-8.8), followed by adalimumab combined with methotrexate (adjusted RRÂ =Â 3.28, 95% CIÂ = 0.8-13.5). Adalimumab in combination with methotrexate had the highest risk of infection recurrence (adjusted RRÂ = 4.33, 95% CIÂ = 2.27-8.24).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Investigative Dermatology - Volume 137, Issue 2, February 2017, Pages 313-321
Journal: Journal of Investigative Dermatology - Volume 137, Issue 2, February 2017, Pages 313-321
نویسندگان
Paula Dávila-Seijo, Esteban Dauden, M.A. Descalzo, Gregorio Carretero, José-Manuel Carrascosa, Francisco Vanaclocha, Francisco-José Gómez-GarcÃa, Pablo De la Cueva-Dobao, Enrique Herrera-Ceballos, Isabel Belinchón, José-Luis López-Estebaranz,