کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5649844 | 1407134 | 2017 | 29 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Shared Oncogenic Pathways Implicated in Both Virus-Positive and UV-Induced Merkel Cell Carcinomas
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
MCCNFATSSMp-CREBRTKphosphorylated signal transducer and activator of transcriptionMCPyVImmunohistochemistry - ایمونوهیستوشیمیIHC - ایمونوهیستوشیمیKEGG یا Kyoto Encyclopedia of Genes and Genomes - دایرة المعارف ژن ها و ژنوم کیوتو Kyoto Encyclopedia of Genes and Genomes - دایره المعارف ژنتیک ژن ها و ژنوم کیوتوretinoblastoma - رتینوبلاستوما، تومور شبکیهNuclear Factor of Activated T Cells - عامل هسته ای سلول های T فعال شدهMerkel cell polyomavirus - ویروس مولکولی سلول مرکلMerkel cell carcinoma - کارسینوم سلول مرکل
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
امراض پوستی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Merkel cell carcinoma (MCC) is a highly malignant neuroendocrine tumor of the skin whose molecular pathogenesis is not completely understood, despite the role that Merkel cell polyomavirus can play in 55-90% of cases. To study potential mechanisms driving this disease in clinically characterized cases, we searched for somatic mutations using whole-exome sequencing, and extrapolated our findings to study functional biomarkers reporting on the activity of the mutated pathways. Confirming previous results, Merkel cell polyomavirus-negative tumors had higher mutational loads with UV signatures and more frequent mutations in TP53 and RB compared with their Merkel cell polyomavirus-positive counterparts. Despite important genetic differences, the two Merkel cell carcinoma etiologies both exhibited nuclear accumulation of oncogenic transcription factors such as NFAT or nuclear factor of activated T cells (NFAT), P-CREB, and P-STAT3, indicating commonly deregulated pathogenic mechanisms with the potential to serve as targets for therapy. A multivariable analysis identified phosphorylated CRE-binding protein as an independent survival factor with respect to clinical variables and Merkel cell polyomavirus status in our cohort of Merkel cell carcinoma patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Investigative Dermatology - Volume 137, Issue 1, January 2017, Pages 197-206
Journal: Journal of Investigative Dermatology - Volume 137, Issue 1, January 2017, Pages 197-206
نویسندگان
MarÃa del Carmen González-Vela, Soraya Curiel-Olmo, Sophia Derdak, Sergi Beltran, Miguel Santibañez, Nerea MartÃnez, Alfredo Castillo-Trujillo, Martha Gut, Roxana Sánchez-Pacheco, Carmen Almaraz, Laura Cereceda, Beatriz Llombart,