کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5817942 1557330 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Towards a rational basis for selection of excipients: Excipient Efficiency for controlled release
ترجمه فارسی عنوان
به یک مبنای منطقی برای انتخاب امولسیون: کارایی اکسیژن برای کنترل آزاد شده
کلمات کلیدی
کارایی اکسیژن، آزادی کنترل دارویی، اندازه ذرات، قطر بینی، نقاط بحرانی، انحلال پذیری،
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
چکیده انگلیسی

There are many factors influencing the drug release behaviour from a pharmaceutical formulation as the particle size of the drug and excipient, porosity of the system or geometrical phase transitions of the components. Therefore, the choice of the adequate excipient to achieve a specific drug release profile is mainly based on the experience and the trial and error method. Taking into account the directives towards the application of the “Quality by Design” approach, in this study the Excipient Efficiency (EE), a parameter able to quantify the capability of an excipient to control the drug release, has been developed. EE was initially calculated dividing the total porosity of the system by its diffusional release rate constant. The influence of several factors on this parameter has been evaluated. As a result, the final parameter has been corrected based on the drug solubility and the excipient particle size. EE provides a rational basis for identifying the most adequate excipients for a concrete formulation.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 494, Issue 1, 15 October 2015, Pages 288-295
نویسندگان
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