کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5822006 | 1557824 | 2015 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
AIM2 co-immunization favors specific multifunctional CD8+ T cell induction and ameliorates coxsackievirus B3-induced chronic myocarditis
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کلمات کلیدی
Chronic myocarditisDCMLVEFTCID50PRRsCVB3Coxsackievirus B3AIM2CVFLVEDdLVFSTnI - TNITroponin I - تروپونین IDNA vaccine - واکسن DNA absent in melanoma 2 - وجود ندارد در ملانوم 2Dilated cardiomyopathy - کاردیومیوپاتی دیلاته، کاردیومیوپاتی کاملcollagen volume fraction - کسر حجم کلاژنleft ventricular ejection fraction - کسر خروجی بطن چپtissue culture infective dose 50% - کشت بافتی دوز عفونت 50٪left ventricular fractional shortening - کوتاه شدن بطن چپ باریکChitosan - کیتوسان pattern recognition receptors - گیرنده های تشخیص الگو
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ویروس شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: AIM2 co-immunization favors specific multifunctional CD8+ T cell induction and ameliorates coxsackievirus B3-induced chronic myocarditis AIM2 co-immunization favors specific multifunctional CD8+ T cell induction and ameliorates coxsackievirus B3-induced chronic myocarditis](/preview/png/5822006.png)
چکیده انگلیسی
Coxsackievirus B3 (CVB3) infection can cause acute myocarditis and chronic myocarditis, leading to dilated cardiomyopathy (DCM) with no effective therapeutic strategy. Therefore, we investigated the potential of absent in melanoma 2 (AIM2) to enhance the therapeutic efficacy of DNA vaccine against CVB3-induced chronic myocarditis. Mice were infected with CVB3 and then intranasally immunized with chitosan-pcDNA3.1 (mock), chitosan-pAIM2 (CS-pAIM2), chitosan-pVP1 (CS-pVP1), or chitosan-pAIM2 plus chitosan-pVP1 (CS-pAIM2/CS-pVP1) at 7, 21, and 35Â d. Therapeutic efficacies of various vaccines were evaluated at day 56Â d. Compared with CS-pVP1 immunization, CS-pAIM2/CS-pVP1 co-immunization significantly increased survival rate, improved cardiac function, as well as decreased myocardial injury and fibrosis, this result indicated that CVB3-induced chronic myocarditis was alleviated. CVB3-specific T lymphocyte proliferation and cytotoxic T lymphocyte responses of the CS-pAIM2/CS-pVP1 co-immunization group were also increased. More interestingly, CS-pAIM2/CS-pVP1 co-immunization could facilitate CVB3-specific multifunctional CD8+ T cell induction in the intestinal mucosa, and this induction was closely correlated with myocardial scores, this result indicated that CS-pAIM2/CS-pVP1 vaccine exhibits therapeutic efficacy by enhancing multifunctional CD8+ T cells. This study may represent a novel therapy for CVB3-induced chronic myocarditis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Antiviral Research - Volume 119, July 2015, Pages 68-77
Journal: Antiviral Research - Volume 119, July 2015, Pages 68-77
نویسندگان
Dafei Chai, Yan Yue, Wei Xu, Chunsheng Dong, Sidong Xiong,