کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5837973 | 1123974 | 2012 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Immunomodulatory active compounds from Tinospora cordifolia
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کلمات کلیدی
DEPTESI-QTOF-MSSesquiterpenesTinospora cordifoliaHMQCNBTPMNnuclear magnetic resonance - رزونانس مغناطیسی هستهایPMA - LDC هاROS - ROSnitroblue tetrazolium - tetrazolium nitroblueAlkaloids - آلکالوئیدdistortionless enhancement by polarization transfer - افزایش تحرک توسط انتقال قطبشNitrous oxide - اکسید نیتروژنNMR - تشدید مغناطیسی هستهای minimum essential medium - حداقل حداقل مورد نیازMass spectrometry - طیف سنجی جرمیphorbol myristate acetate - فروبل مریستات استاتImmunomodulatory activity - فعالیت ایمن سازیMEM - مامانpolymorphonuclear neutrophil - نوتروفیل پلی مرفون هسته ایHMBC یا Heteronuclear Multiple Bond Correlation - همبستگی پیوند چندگانه ناجورهستهHeteronuclear Multiple Quantum Correlation - همبستگی کوانتومی چندگانه چند هسته ایReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
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چکیده انگلیسی
Ethnopharmacological relevanceTinospora cordifolia mentioned as “Rasayana” is extensively used in various herbal preparations for the treatment of different ailments for its general tonic, antiperiodic, antispasmodic, antiinflammatory, antiarthritic, antiallergic and antidiabetic properties. It is extensively used in Ayurveda due to its potential in improving the immune system and the body resistance against infections.Aim of the studyThe aim of the study was to isolate and characterise the immunomodulatory active compounds of Tinospora cordifolia.Materials and methodsThe immunomodulatory activity of different extracts, fractions and isolated compounds in relation to phagocytosis and reactive oxygen species production in human neutrophil cells have been investigated using the PMN phagocytic function studies, NBT, NO and chemiluminescence assay.ResultsThe results obtained indicate that ethyl acetate, water fractions and hot water extract exhibited significant immunomodulatory activity with an increase in percentage phagocyctosis. Chromatographic purification of these fraction led to the isolation of a mixture of two compounds 2, 3 isolated for the first time from natural source and five known compounds 1, 4-7 which were characterized as 11-hydroxymustakone (2), N-methyl-2-pyrrolidone (3), N-formylannonain (1), cordifolioside A (4), magnoflorine (5), tinocordiside (6), syringin (7) by nuclear magnetic resonance (NMR) and mass spectrometry (MS) and comparing the spectral data with reported one. Cordifolioside A and syringin have been reported to possess immunomodulatory activity. Other five compounds showed significant enhancement in phagocytic activity and increase in nitric oxide and reactive oxygen species generation at concentration 0.1-2.5 μg/ml.ConclusionsSeven immunomodulatory active compounds belonging to different classes have been isolated and characterised indicating that the immunomodulatory activity of Tinospora cordifolia may be attributed to the synergistic effect of group of compounds.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 141, Issue 3, 14 June 2012, Pages 918-926
Journal: Journal of Ethnopharmacology - Volume 141, Issue 3, 14 June 2012, Pages 918-926
نویسندگان
Upendra Sharma, Manju Bala, Neeraj Kumar, Bikram Singh, Renuka K. Munshi, Supriya Bhalerao,